Scientific Publications

In recent years, the increasing commitment of TLS to in-house research has produced a significant growth of the scientific contribution of the foundation’s researchers, with publications in major international scientific journals such as The Lancet, Nature, Cell, Current Opinion in Immunology, Frontiers in Oncology, PNAS.
This is a clear demonstration of the strengthening of the TLS R&D activities owing to the presence of PhD students, to the work performed by the groups involved in the various scientific projects but also to the research activities carried out for third parties.

Authors Title Science Journal DOI
D’Errico G, Duda-Sikula M, Zwiefka A, Krzyzanowski D, Kurpas D. Health technologies and smart & integrated care–key action 2 stage of the Regions4PerMed (H2020) project Medical Science Pulse. 2019;13(4) Link
Moramarco F, Pezzicoli A, Salvini L, Leuzzi R, Pansegrau W, Balducci E. A LONELY GUY protein of Bordetella pertussis with unique features is related to oxidative stress Scientific reports. 2019 Nov 19;9(1):1-2 Link
Tagliabue A, Leite LC, Leroy OY, Rappuoli R. A global perspective on vaccines: priorities, challenges and online information Frontiers in immunology. 2019 Nov 12;10:2556. Link
Paolino M, Visintin M, Margotti E, Visentini M, Salvini L, Reale A, Razzano V, Giuliani G, Caselli G, Tavanti F, Menziani MC, Cappelli A. Functionalization of protein hexahistidine tags by functional nanoreactors New Journal of Chemistry. 2019;43(46):17946-53 Link
Irene C, Fantappiè L, Caproni E, Zerbini F, Anesi A, Tomasi M, Zanella I, Stupia S, Prete S, Valensin S, König E, Frattini L, Gagliardi A, Isaac SJ, Grandi A, Guella G, Grandi G. Bacterial outer membrane vesicles engineered with lipidated antigens as a platform for Staphylococcus aureus vaccine Proceedings of the National Academy of Sciences. 2019 Oct 22;116(43):21780-8 Link
Zurli V, Montecchi T, Heilig R, Poschke I, Volkmar M, Wimmer G, Boncompagni G, Turacchio G, D’Elios MM, Campoccia G, Resta N, Offringa R, Fischer R, Acuto O, Baldari CT, Kabanova A. Phosphoproteomics of CD2 signaling reveals an AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells bioRxiv. 2019 Jan 1:795963 Link
D’Errico G, Cormio PG, Bello P, Duda-Sikuła M, Zwiefka A, Krzyżanowski, EA Stegemann, BA Requeijo, JM Romero Fidalgo, D Kurpas. Interregional coordination for a fast and deep uptake of personalised health (Regions4Permed) –multidisciplinary consortium under the H2020 project Medical Science Pulse 2019 (13) 3© Copyright by PMWSZ w Opolu. 2019 Jul 1;13:60. Link
Paolino M, Reale A, Razzano V, Giuliani G, Donati A, Giorgi G, Boccia AC, Mendichi R, Piovani D, Botta C, Salvini L, Samperi F, Savoca C, Licciardi M, Paccagnini E, Gentile M, Cappelli A. Physicochemical properties of a new pegylated polybenzofulvene brush for drug encapsulation Pharmaceutics. 2019 Sep;11(9):444. Link
Cicaloni V, Spiga O, Dimitri GM, Maiocchi R, Millucci L, Giustarini D, Bernardini G, Bernini A, Marzocchi B, Braconi D, Santucci A. Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease The FASEB Journal. 2019 Nov;33(11):12696-703 Link
Andreano E, Seubert A, Rappuoli R. Human monoclonal antibodies for discovery, therapy, and vaccine acceleration Current opinion in immunology. 2019 Aug 1;59:130-4 Link
Seib KL, Haag AF, Oriente F, Fantappiè L, Borghi S, Semchenko EA, Schulz BL, Ferlicca F, Taddei AR, Giuliani MM, Pizza M, Delany I. The meningococcal vaccine antigen GNA2091 is an analogue of YraP and plays key roles in outer membrane stability and virulence The FASEB Journal. 2019 Nov;33(11):12324-35 Link
Andreano E, D'Oro U, Rappuoli R, Finco O. Vaccine evolution and its application to fight modern threats Frontiers in immunology. 2019 Jul 25;10:1722 Link
Gerna G, Kabanova A, Lilleri D. Human cytomegalovirus cell tropism and host cell receptors Vaccines. 2019 Sep;7(3):70 Link
Paolino M, Reale A, Razzano V, Giuliani G, Donati A, Bonechi C, Caselli G, Visintin M, Makovec F, Scialabba C, Licciardi M, Paccagnini E, Gentile M, Salvini L, Tavanti F, Menziani MC, Cappelli A. Nanoreactors for the multi-functionalization of poly-histidine fragments New Journal of Chemistry. 2019;43(18):6834-7 Link
Ascher DB, Spiga O, Sekelska M, Pires DE, Bernini A, Tiezzi M, Kralovicova J, Borovska I, Soltysova A, Olsson B, Galderisi S, Cicaloni V, Ranganath L, Santucci A, Zatkova A. Homogentisate 1, 2-dioxygenase (HGD) gene variants, their analysis and genotype–phenotype correlations in the largest cohort of patients with AKU European Journal of Human Genetics. 2019 Jun;27(6):888-902 Link
Authors Title Science Journal DOI
Andreano E, Piccini G, Licastro D, Casalino L, Johnson NV, Paciello I, Dal Monego S, Pantano E, Manganaro N, Manenti A, Manna R, Casa E, Hyseni I, Benincasa L, Montomoli E, Amaro RE, McLellan JS, Rappuoli R. SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma BioRxiv. 2020 Jan 1 Link
Kabanova A, Gavriilaki E, Pelzer BW, Brunetti L, Maiques-Diaz A. Effect of the COVID-19 pandemic on laboratory and clinical research: a testimony and a call to action from researchers HemaSphere. 2020 Dec;4(6) Link
Ristori E, Cicaloni V, Salvini L, Tinti L, Tinti C, Simons M, Corti F, Donnini S, Ziche M. Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells Cells. 2020 Nov;9(11):2506 Link
Borges NM, Kabanova A, Scherer F. Change is Coming: Plan S From the Early Career Scientist Perspective HemaSphere. 2020 Dec;4(6) Link
Ciabattini A, Garagnani P, Santoro F, Rappuoli R, Franceschi C, Medaglini D. Shelter from the cytokine storm: Pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population InSeminars in immunopathology 2020 Nov 6 (pp. 1-16). Springer Berlin Heidelberg Link
Cicaloni V, Pecorelli A, Cordone V, Tinti L, Rossi M, Hayek J, Salvini L, Tinti C, Valacchi G. A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome Archives of Biochemistry and Biophysics. 2020 Dec 15; 696:108660 Link
Schneikart G, Tavarini S, Sammicheli C, Torricelli G, Guidotti S, Andreano E, Buricchi F, D'Oro U, Finco O, Bardelli M The respiratory syncytial virus fusion protein-specific B cell receptor repertoire reshaped by post-fusion subunit vaccination Vaccine. 2020 Nov 25;38(50):7916-27. Link
Troisi M, Andreano E, Sala C, Kabanova A, Rappuoli R. Vaccines as remedy for antimicrobial resistance and emerging infections Current Opinion in Immunology. 2020 Aug 1; 65:102-6 Link
Sala C, Benjak A, Goletti D, Banu S, Mazza-Stadler J, Jaton K, Busso P, Remm S, Leleu M, Rougemont J, Palmieri F, Cuzzi G, Butera O, Vanini V, Kabir S, Rahman SMM, Nicod L, Cole ST. Multicenter analysis of sputum microbiota in tuberculosis patients PloS one. 2020 Oct 12;15(10):e0240250 Link
Andreano E, Nicastri E, Paciello I, Pileri P, Manganaro N, Piccini G, Manenti A, Pantano E, Kabanova A, Troisi M, Vacca F, Cardamone D, De Santi C, Benincasa L, Agrati C, Capobianchi MR, Castilletti C, Emiliozzi A, Fabbiani M, Montagnani F, Depau L, Brunetti J, Bracci L, Montomoli E, Sala C, Ippolito G, Rappuoli R. Extremely potent human monoclonal antibodies from convalescent Covid-19 patients bioRxiv. 2020 Jan 1 Link
Bucci E, Andreev K, Björkman A, Calogero RA, Carafoli E, Carninci P, Castagnoli P, Cossarizza A, Mussini C, Guerin P, Lipworth B, Sbardella G, Stocki T, Tuosto L, van Tulleken C, Viola A. Safety and efficacy of the Russian COVID-19 vaccine: more information needed The Lancet. 2020 Oct 3;396(10256):e53 Link
Sala C, Chiarelli LR, Riccardi G. Editorial on Special Issue “Tuberculosis Drug Discovery and Development 2019” Applied Sciences. 2020;10(17):6069 Link
Ricciardi-Castagnoli P. Sensing the gut microbiota Nature Immunology. 2020 Jul;21(7):704-5 Link
Rossi A, Giacomini G, Cicaloni V, Galderisi S, Milella MS, Bernini A, Millucci L, Spiga O, Bianchini M, Santucci A. AKUImg: A database of cartilage images of Alkaptonuria patients Computers in Biology and Medicine. 2020 Jul 1; 122:103863 Link
Maio M, Hamid O, Larkin J, Covre A, Altomonte M, Calabrò L, Vardhana SA, Robert C, Ibrahim R, Anichini A, Wolchok JD, Giacomo AMD. Immune checkpoint inhibitors for cancer therapy in the COVID-19 era Clinical Cancer Research. 2020 Aug 15;26(16):4201-5 Link
Rappuoli R. Drugs and Vaccines Will Be Necessary to Control Tuberculosis Applied Sciences. 2020;10(11):4026 Link
Rosini R, Nicchi S, Pizza M, Rappuoli R. Vaccines against antimicrobial resistance. Frontiers in immunology. 2020 Jun 3;11:1048. Link
Montico B, Colizzi F, Giurato G, Rizzo A, Salvati A, Baboci L, Benedetti D, Pivetta E, Covre A, Dal Bo M, Weisz A, Steffan A, Maio M, Sigalotti L, Fratta E. Loss of Spry1 reduces growth of BRAF V600-mutant cutaneous melanoma and improves response to targeted therapy Cell death & disease. 2020 May 22;11(5):1-5 Link
Cicaloni V, Pecorelli A, Tinti L, Rossi M, Benedusi M, Cervellati C, Spiga O, Santucci A, Hayek J, Salvini L, Tinti C, Valacchi G. Proteomic profiling reveals mitochondrial alterations in Rett syndrome Free Radical Biology and Medicine. 2020 Aug 1; 155:37-48 Link
Andreano E, Nicastri E, Paciello I, Pileri P, Manganaro N, Piccini G, Manenti A, Pantano E, Kabanova A, Troisi M, Vacca F, Cardamone D, De Santi C, Agrati C, Capobianchi MR, Castilletti C, Emiliozzi A, Fabbiani M, Montagnani F, Montomoli E, Sala C, Ippolito G, Rappuoli R. Identification of neutralizing human monoclonal antibodies from Italian Covid-19 convalescent patients bioRxiv. 2020 Jan 1 Link
Medaglini D, Andersen P, Rappuoli R. Advanced Immunization Technologies for Next Generation Vaccines Frontiers in Immunology. 2020 May 6;11:878 Link
Pieterman ED, Sarink MJ, Sala C, Cole ST, de Steenwinkel JE, Bax HI. Advanced quantification methods to improve the 18b dormancy model for assessing the activity of tuberculosis drugs in vitro Antimicrobial agents and chemotherapy. 2020 Apr 27;64(7): e00280-20 Link
Gries R, Sala C, Rybniker J. Host-directed therapies and anti-virulence compounds to address anti-microbial resistant tuberculosis infection Applied Sciences. 2020 Jan;10(8):2688. Link
Spiga O, Cicaloni V, Fiorini C, Trezza A, Visibelli A, Millucci L, Bernardini G, Bernini A, Marzocchi B, Braconi D, Prischi F, Santucci A. Machine learning application for development of a data-driven predictive model able to investigate quality of life scores in a rare disease Orphanet journal of rare diseases 2020 Dec;15(1):1-0 Link
Milazzo FM, Vesci L, Anastasi AM, Chiapparino C, Rosi A, Giannini G, Taddei M, Cini E, Faltoni V, Petricci E, Battistuzzi G, Salvini L, Carollo V, De Santis R. ErbB2 targeted epigenetic modulation: anti-tumor efficacy of the ADC trastuzumab-HDACi ST8176AA1 Frontiers in oncology. 2020 Jan 23; 9:1534 Link
Aarestrup FM, Albeyatti A, Armitage WJ, Auffray C, Augello L, Balling R, Benhabiles N, Bertolini G, Bjaalie JG, Black M, Blomberg N, Bogaert P, Bubak M, Claerhout B, Clarke L, De Meulder B, D'Errico G, Di Meglio A, Forgo N, Gans-Combe C, Gray AE, Gut I, Gyllenberg A, Hemmrich-Stanisak G, Hjorth L, Ioannidis Y, Jarmalaite S, Kel A, Kherif F, Korbel JO, Larue C, Laszlo M, Maas A, Magalhaes L, Manneh-Vangramberen I, Morley-Fletcher E, Ohmann C, Oksvold P, Oxtoby NP, Perseil I, Pezoulas V, Riess O, Riper H, Roca J, Rosenstiel P, Sabatier P, Sanz F, Tayeb M, Thomassen G, Van Bussel J, Van den Bulcke M, Van Oyen H. Towards a European health research and innovation cloud (HRIC) Genome medicine. 2020 Dec;12(1):1-4 Link
Authors Title Science Journal DOI
Andreano E, Paciello I, Piccini G, Manganaro N, Pileri P, Hyseni I, Leonardi M, Pantano E, Abbiento V, Benincasa L, Giglioli G, De Santi C, Fabbiani M, Rancan I, Tumbarello M, Montagnani F, Sala C, Montomoli E, Rappuoli R. Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants. Nature. 2021 Dec;600(7889):530-535. Link
Vanni F, Lopresti L, Zurli V, Kabanova A, Cattaneo F, Sicuranza A, Gozzetti A, Gemma S, Zisterer DM, Bocchia M, Campiani G, Baldari CT, Butini S, Ulivieri C. A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis. Pharmacol Res. 2021 Dec; 174:105965. Link
Tomasi M, Dalsass M, Beghini F, Zanella I, Caproni E, Fantappiè L, Gagliardi A, Irene C, König E, Frattini L, Masetti G, Isaac SJ, Armanini F, Cumbo F, Blanco-Míguez A, Grandi A, Segata N, Grandi G. Commensal Bifidobacterium Strains Enhance the Efficacy of Neo-Epitope Based Cancer Vaccines. Vaccines (Basel). 2021 Nov 18;9(11):1356. Link
König E, Gagliardi A, Riedmiller I, Andretta C, Tomasi M, Irene C, Frattini L, Zanella I, Berti F, Grandi A, Caproni E, Fantappiè L, Grandi G. Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Staphylococcus aureus Case. Front Immunol. 2021 Nov 8;12:752168. Link
Andreano E, Piccini G, Licastro D, Casalino L, Johnson NV, Paciello I, Dal Monego S, Pantano E, Manganaro N, Manenti A, Manna R, Casa E, Hyseni I, Benincasa L, Montomoli E, Amaro RE, McLellan JS, Rappuoli R. SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma Proceedings of the National Academy of Sciences. 2021 Sep 7;118(36) Link
Andreano E, Paciello I, Piccini G, Manganaro N, Pileri P, Hyseni I, Leonardi M, Pantano E, Abbiento V, Benincasa L, Giglioli G, De Santi C, Fabbiani M, Rancan I, Tumbarello M, Montagnani F, Sala C, Montomoli E, Rappuoli R. Hybrid immunity improves B cell frequency, antibody potency and breadth against SARS-CoV-2 and variants of concern bioRxiv. 2021 Jan 1 Link
Lanini S, Milleri S, Andreano E, Nosari S, Paciello I, Piccini G, Gentili A, Phogat A, Hyseni I, Leonardi M, Torelli A, Montomoli E, Paolini A, Frosini A, Antinori A, Nicastri E, Girardi E, Plazzi MM, Ippolito G, Vaia F, Della Cioppa G, Rappuoli R. A single intramuscular injection of monoclonal antibody MAD0004J08 induces in healthy adults SARS-CoV-2 neutralising antibody titres exceeding those induced by infection and vaccination medRxiv. 2021 Jan 1 Link
Pagano C, Baiocchi C, Beccari T, Blasi F, Cossignani L, Ceccarini MR, Orabona C, Orecchini E, Di Raimo E, Primavilla S, Salvini L, Di Michele A, Perioli L, Ricci M. Emulgel Loaded with Flaxseed Extracts as New Therapeutic Approach in Wound Treatment Pharmaceutics. 2021 Aug;13(8):1107 Link
Stravalaci M, Pagani I, Paraboschi EM, Pedotti M, Doni A, Scavello F, Mapelli SN, Sironi M, Varani L, Matkovic M, Cavalli A, Cesana D, Gallina P, Pedemonte N, Capurro V, Clementi N, Mancini N, Invernizzi P, Rappuoli R, Duga S, Bottazzi B, Uguccioni M, Asselta R, Vicenzi E, Mantovani A, Garlanda C. Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules medRxiv. 2021 Jan 1 Link
Minenkova O, Santapaola D, Milazzo FM, Anastasi AM, Battistuzzi G, Chiapparino C, Rosi A, Gritti G, Borleri G, Rambaldi A, Dental C, Viollet C, Pagano B, Salvini L, Marra E , Luberto L, Rossi A, Riccio A, Merlo Pich E, Santoro MG and De Santis R, Human single-chain antibodies neutralize SARS-CoV-2 variants by engaging an essential epitope of the spike: a new weapon against COVID-19 bioRxiv 2021.06.04.447066; Link
Romagnuolo I, Mariut C, Mazzoni A, Santis GD, Moltzen E, Ballensiefen W, Lange C, Frosini A, D’Errico G. Sino-European science and technology collaboration on personalized medicine: overview, trends and future perspectives Personalized Medicine. vol. 18, no. 5, pp. 455–470, 2021. Link
Pettini F, Visibelli A, Cicaloni V, Iovinelli D, Spiga O. Multi-Omics Model Applied to Cancer Genetics International Journal of Molecular Sciences. 2021 Jan;22(11):5751 Link
Andreano E, Rappuoli R. SARS-CoV-2 escaped natural immunity, raising questions about vaccines and therapies Nature Medicine. 2021 May;27(5):759-61 Link
Nardini C, Osmani V, Cormio PG, Frosini A, Turrini M, Lionis C, Neumuth T, Ballensiefen W, Borgonovi E, D’Errico G. The evolution of personalized healthcare and the pivotal role of European regions in its implementation Personalized Medicine. 2021 May;18(3):283-94. Link
Andreano E, Rappuoli R. Immunodominant antibody germlines in COVID-19. J Exp Med. 2021 May 3;218(5):e20210281. Link
Andreano E, Nicastri E, Paciello I, Pileri P, Manganaro N, Piccini G, Manenti A, Pantano E, Kabanova A, Troisi M, Vacca F, Cardamone D, De Santi C, Torres JL, Ozorowski G, Benincasa L, Jang H, Di Genova C, Depau L, Brunetti J, Agrati C, Capobianchi MR, Castilletti C, Emiliozzi A, Fabbiani M, Montagnani F, Bracci L, Sautto G, Ross TM, Montomoli M, Temperton N, Ward AB, Sala C, Ippolito G, Rappuoli R. Extremely potent human monoclonal antibodies from COVID-19 convalescent patients Cell. 2021 Apr 1;184(7):1821-35.e16. Link
Zanella I, König E, Tomasi M, Gagliardi A, Frattini L, Fantappiè L, Irene C, Zerbini F, Caproni E, Isaac SJ, Grigolato M, Corbellari R, Valensin S, Ferlenghi I, Giusti F, Bini L, Ashhab Y, Grandi A, Grandi G. Proteome‐minimized outer membrane vesicles from Escherichia coli as a generalized vaccine platform Journal of extracellular vesicles. 2021 Feb;10(4):e12066 Link
Spiga O, Cicaloni V, Dimitri GM, Pettini F, Braconi D, Bernini A, Santucci A. Machine learning application for patient stratification and phenotype/genotype investigation in a rare disease. Briefings in Bioinformatics. 2021 Sep;22(5):bbaa434. Link
Braconi D, Cicaloni V, Spiga O, Santucci A. Personalized nutrition and omics technologies: current status and perspectives Food Technology Disruptions. 2021 Jan 1:37-71 Link
Pecetta S, Pizza M, Sala C, Andreano E, Pileri P, Troisi M, Pantano E, Manganaro N, Rappuoli R. Antibodies, epicenter of SARS-CoV-2 immunology Cell Death & Differentiation. 2021 Feb;28(2):821-824 Link
Spiga O, Cicaloni V, Visibelli A, Davoli A, Paparo MA, Orlandini M, Vecchi B, Santucci A. Towards a precision medicine approach based on machine learning for tailoring medical treatment in alkaptonuria International journal of molecular sciences. 2021 Jan;22(3):1187 Link
Galderisi S, Cicaloni V, Milella MS, Millucci L, Geminiani M, Salvini L, Tinti L, Tinti C, Vieira OV, Alves LS, Crevenna AH, Spiga O, Santucci A. Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage Journal of Cellular Physiology. 2021 Aug;236(8):6011-24 Link
Cianferotti C, Faltoni V, Cini E, Ermini E, Migliorini F, Petricci E, Taddei M, Salvini L, Battistuzzi G, Milazzo FM, Anastasi AM, Chiapparino C, De Santis R, Giannini G. Antibody drug conjugates with hydroxamic acid cargos for histone deacetylase (HDAC) inhibition Chemical Communications. 2021;57(7):867-70 Link
Grieco G, Brusco N, Nigi L, Formichi C, Fignani D, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F. Reduced miR-184-3p expression occurring in Type 2 diabetic pancreatic islets protects β-cells from lipotoxic and proinflammatory apoptosis via a CRTC1-dependent mechanism bioRxiv 2021.01.04.425234; Link
Karmakar M, Cicaloni V, Rodrigues CH, Spiga O, Santucci A, Ascher DB. HGDiscovery: an online tool providing functional and phenotypic information on novel variants of homogentisate 1, 2-dioxigenase. bioRxiv. 2021 Jan 1. Link
Jonathan L. Torres, Gabriel Ozorowski, Emanuele Andreano, Hejun Liu, Jeffrey Copps, Giulia Piccini, Lorena Donnici, Matteo Conti, Cyril Planchais, Delphine Planas, Noemi Manganaro, Elisa Pantano, Ida Paciello, Piero Pileri, Timothée Bruel, Emanuele Montomoli, Hugo Mouquet, Olivier Schwartz, Claudia Sala, Raffaele De Francesco, Ian Wilson, Rino Rappuoli, Andrew B. Ward. Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody bioRxiv. 2021 Oct 9. Link
Selvaggio G, Leonardelli L, Lofano G, Fresnay S, Parolo S, Medini D, Siena E, Marchetti L. A quantitative systems pharmacology approach to support mRNA vaccine development and optimization. CPT Pharmacometrics Syst Pharmacol. 2021 Dec;10(12):1448-1451. Link
Leonardelli L, Lofano G, Selvaggio G, Parolo S, Giampiccolo S, Tomasoni D, Domenici E, Priami C, Song H, Medini D, Marchetti L, Siena E. Literature Mining and Mechanistic Graphical Modelling to Improve mRNA Vaccine Platforms. Front Immunol. 2021 Sep 7;12:738388. Link
Calabrò L, Rossi G, Morra A, Rosati C, Cutaia O, Daffinà MG, Altomonte M, Di Giacomo AM, Casula M, Fazio C, Palmieri G, Giannarelli D, Covre A, Maio M. Tremelimumab plus durvalumab retreatment and 4-year outcomes in patients with mesothelioma: a follow-up of the open label, non-randomised, phase 2 NIBIT- MESO-1 study. Lancet Respir Med. 2021 Sep;9(9):969-976. Link
Sonia Budroni, Francesca Buricchi, AndreaCavallone, Gianfranco Volpini, Alessandra Mariani, Paola Lo Surdo, Christoph J.Blohmke, Giuseppe Del Giudice, Duccio Medini, Oretta Finco Computational modeling of microfluidic data provides high-throughput affinity estimates for monoclonal antibodies Computational and Structural Biotechnology Journal, Volume 19, 2021, Pages 3664-3672 Link
Pecorelli A, Cordone V, Schiavone ML, Caffarelli C, Cervellati C, Cerbone G, Gonnelli S, Hayek J, Valacchi G. Altered Bone Status in Rett Syndrome. Life (Basel). 2021 Jun 3;11(6):521. Link
Crivellari I, Pecorelli A, Cordone V, Marchi S, Pinton P, Hayek J, Cervellati C, Valacchi G. Impaired mitochondrial quality control in Rett Syndrome. Arch Biochem Biophys. 2021 Mar 30;700:108790. Link
Alessio Mascolini, Dario Cardamone, Francesco Ponzio, Santa Di Cataldo, Elisa Ficarra Exploiting generative self-supervised learning for the assessment of biological images with lack of annotations: a COVID-19 case-study arXiv Link

Join the TLS mailing list Subscribe

TLS Research

visit the other sections

Research Projects

TLS is involved in an increasing number of research projects aimed at responding to major health challenges such as bacterial resistance to antibiotics or orphan diseases.