TLS is involved in an increasing number of research projects aimed at responding to major health challenges such as bacterial resistance to antibiotics or orphan diseases, as well as at investigating the mechanisms of progression and regression of leukemia and blood cancers or the effectiveness of the application of vaccines to immuno-oncology.
The Foundation is currently the host institution of important research projects, three of which are funded by the European Research Council (ERC), one by the Wellcome Trust, one by the Wellcome Leap and one made possible thanks to funding from AIRC (Italian Association for Cancer Research).
In particular, following the spread of the SARS-CoV-2 coronavirus, in March 2020 TLS promptly started the MAbCo19 project for the development of a cure for COVID-19, relying on the expertise of the MAD Lab and on important sources of funding.
TLS has also consolidated its third-party research and development activities, for which it is involved in important projects mainly related to the use of skills and expertise in proteomics.
Research Projects
BOTANICALS LAB
The Botanicals Lab is an laboratory that combines the regulatory expertise in food supplements of Linneus Consulting with the laboratory know-how and analytical research services for the Botanicals sector provided by the Mass Spectrometry Unit (MSU).
DATA SCIENCE FOR HEALTH (DASCH) LAB
The DaScH-Lab can rely on the expertise of a diverse group of computational and machine-learning scientists working at the interface with experimental teams on a wide range of life science challenges.
Hyper Antibody Research Development (HARD) LAB
The High-Throughput Antibody Research and Development Lab (HARD-Lab) is dedicated to cutting-edge research and development in the field of antibody-based diagnostics and therapeutics, focusing on areas of medical importance such as oncology, metabolic, infectious, and rare diseases.
MASS SPECTROMETRY UNIT
The Mass Spectrometry Unit (MSU) is a well-established reality within TLS consisting of a multidisciplinary team which, by combining mass spectrometry with bioinformatic data processing, deals with the cross-sectional analysis of a wide variety of samples to investigate their protein and metabolic profile.
ORPHAN DISEASES
Fondazione Toscana Life Sciences has explicitly identified among its institutional objectives a strategic role in the field of rare diseases, with particular emphasis on acting as a translational bridge between basic research and industrial applications in the biomedical and pharmaceutical sectors
Molecular Immunology and Translational Oncology (MITO) Lab
The Molecular Immunology and Translational Oncology (MITO) laboratory, led by Dr. Anna Kabanova, was established in 2019 with the support of the Italian Association for Cancer Research (AIRC). The MITO team investigates B-cell biology in health and disease, leveraging these insights to disrupt metabolic vulnerabilities in leukemia and engineer synthetic cell and antibody-based therapies.
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Scientific Publications
In recent years, the increasing commitment of TLS to in-house research has produced a significant growth of the scientific contribution of the foundation’s researchers