{"id":23343,"date":"2025-10-03T11:49:30","date_gmt":"2025-10-03T09:49:30","guid":{"rendered":"https:\/\/www.toscanalifesciences.org\/?p=23343"},"modified":"2025-10-03T11:55:45","modified_gmt":"2025-10-03T09:55:45","slug":"studio-di-tls-su-nature-individua-anticorpi-contro-klebsiella","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/studio-di-tls-su-nature-individua-anticorpi-contro-klebsiella\/","title":{"rendered":"Studio di TLS su Nature individua anticorpi contro Klebsiella"},"content":{"rendered":"<p>Pubblicato su <strong>Nature<\/strong>, tra le pi\u00f9 prestigiose riviste scientifiche internazionali, lo studio dal titolo \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41586-025-09391-3\">Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae<\/a>\u201d dedicato a Klebsiella pneumoniae, un batterio resistente agli antibiotici che pu\u00f2 facilmente diffondersi negli ospedali e causare infezioni respiratorie, urinarie e del sangue. Il progetto di ricerca condotto dalla Fondazione Toscana Life Sciences (TLS) \u00e8 stato incentrato sullo sviluppo di anticorpi monoclonali umani (mAb) che attualmente rappresentano soluzioni terapeutiche sicure in oncologia e contro malattie autoimmuni, ma che non hanno ancora trovato applicazione clinica per batteri antibiotico-resistenti.<\/p>\n<p>La ricerca oggetto del paper ha coinvolto ricercatori e ricercatrici del <strong>Monoclonal Antibody Discovery Lab (MAD Lab), della Tumour Immunology Unit e del Data Science for Health Lab (DaScH Lab)<\/strong> della <strong>Fondazione TLS<\/strong>. Lo studio \u00e8 stato coordinato da Anna Kabanova, Rino Rappuoli e Claudia Sala e ha visto in prima linea i ricercatori Emanuele Roscioli, Vittoria Zucconi Galli Fonseca e Soraya Soledad Bosch. Il successo del progetto \u00e8 stato il frutto della collaborazione tra ricercatori e medici provenienti da universit\u00e0 ed enti di ricerca di rilievo nazionale e internazionale: Unit\u00e0 di Malattie Infettive dell\u2019Azienda Universitaria Ospedaliera Pisana, Fondazione Biotecnopolo di Siena, Universit\u00e0 di Siena, Centro Risonanze Magnetiche CERM di Firenze, Area Science Park di Trieste, Hartford Hospital negli Stati Uniti, Monash University di Melbourne in Australia, e l\u2019Universit\u00e9 Paris-Saclay e Bic\u00eatre Hospital Assistance Publique-H\u00f4pitaux de Paris in Francia.<\/p>\n<p>Lo studio \u00e8 nato grazie al supporto della <strong>Regione Toscana<\/strong> nell\u2019ambito del <strong>Centro Regionale di Medicina di Precisione (C.Re.Me.P.)<\/strong> ed \u00e8 proseguito grazie al finanziamento sul progetto <strong>PROREACT del Ministero della Salute<\/strong>, con lo scopo di affrontare una criticit\u00e0 per la salute pubblica. Nel 2018, infatti, un focolaio del batterio Klebsiella pneumoniae di tipo ST147, con un altissimo profilo di resistenza agli antibiotici, ha avuto origine e si \u00e8 rapidamente diffuso in Toscana. Il lavoro di ricerca, coordinato da TLS, si \u00e8 concentrato su ST147 e ha portato all\u2019isolamento di anticorpi monoclonali umani estremamente potenti contro questo batterio.<\/p>\n<p>Dallo studio \u00e8 emerso che uno di questi anticorpi monoclonali, che \u00e8 in grado di riconoscere la superficie pi\u00f9 esterna del batterio (la capsula), protegge contro l\u2019infezione sistemica prodotta dal ceppo isolato a Pisa ma anche contro ceppi di Klebsiella pneumoniae isolati in ospedali di Francia e Australia. Nel complesso, questo lavoro \u00e8 un esempio di un <strong>percorso sperimentale<\/strong> che consente di prevedere <strong>antigeni protettivi<\/strong> contro ceppi batterici antibiotico-resistenti che possono aprire la strada allo sviluppo di <strong>terapie innovative<\/strong> ed efficaci contro questa minaccia globale.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La ricerca oggetto del paper ha coinvolto ricercatori e ricercatrici di TLS. <\/p>\n","protected":false},"author":10,"featured_media":19208,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Studio di TLS su Nature individua anticorpi contro Klebsiella - Toscana Life Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/studio-di-tls-su-nature-individua-anticorpi-contro-klebsiella\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Studio di TLS su Nature individua anticorpi contro Klebsiella - 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