{"id":22249,"date":"2024-11-21T11:39:12","date_gmt":"2024-11-21T10:39:12","guid":{"rendered":"https:\/\/www.toscanalifesciences.org\/?p=22249"},"modified":"2024-11-21T11:41:46","modified_gmt":"2024-11-21T10:41:46","slug":"leucemia-linfatica-cronica-pubblicato-su-leukemia-nuovo-studio-tls","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/leucemia-linfatica-cronica-pubblicato-su-leukemia-nuovo-studio-tls\/","title":{"rendered":"Leucemia linfatica cronica: pubblicato su Leukemia nuovo studio TLS"},"content":{"rendered":"<p>Pubblicato sulla rivista scientifica Leukemia un nuovo studio dal titolo \u201c<a href=\"https:\/\/www.nature.com\/articles\/s41375-024-02442-0\">Apoliprotein E-mediated ferroptosis controls cellular proliferation in chronic lymphocytic leukemia<\/a>\u201d. Il progetto di ricerca \u00e8 stato coordinato dalla <strong>Tumour Immunology Unit<\/strong> della Fondazione Toscana Life Sciences che si occupa di studiare un tumore molto frequente delle cellule B, la leucemia linfatica cronica (LLC). La pubblicazione \u00e8 il frutto della collaborazione con la <strong>Mass Spectrometry Unit<\/strong> di TLS, l\u2019Universit\u00e0 di Siena, l\u2019Universit\u00e0 di Torino, l\u2019Universit\u00e0 di Berkeley e Area Science Park di Trieste.<\/p>\n<p>Lo studio, finanziato dalla Fondazione AIRC per la Ricerca sul Cancro e dal consorzio <strong>HEAL ITALIA<\/strong>, descrive un nuovo circuito di regolazione adottato dalle cellule B leucemiche che coinvolge la proteina sierica Apolipoproteina E. In particolare, i ricercatori TLS hanno dimostrato che Apolipoproteina E \u00e8 in grado di indurre ferroptosi nelle cellule LLC, una morte cellulare indotta da eccessiva ossidazione lipidica. Lo studio TLS aggiunge un nuovo tassello nella comprensione dei meccanismi molecolari alla base della LLC e getta anche le basi per lo sviluppo di approcci terapeutici pi\u00f9 efficaci per il trattamento di pazienti con leucemia linfatica cronica, LLC.<\/p>\n<p>I ricercatori TLS coinvolti nello studio sono: <strong>Federica Nardi, Rosita del Prete, Roberta Drago, Laura Pezzella, Laura Tinti, Vittoria Cicaloni, Laura Salvini<\/strong>, coordinatrice scientifica della Mass Spectrometry Unit, e <strong>Anna Kabanova<\/strong>, coordinatrice scientifica della Tumour Immunology Unit.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La ricerca \u00e8 della Tumour Immunology Unit con MSU di TLS. <\/p>\n","protected":false},"author":10,"featured_media":22250,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - 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