{"id":22102,"date":"2024-10-15T12:31:46","date_gmt":"2024-10-15T10:31:46","guid":{"rendered":"https:\/\/www.toscanalifesciences.org\/?p=22102"},"modified":"2024-10-15T12:32:27","modified_gmt":"2024-10-15T10:32:27","slug":"leucemia-linfatica-cronica-su-hemasphere-nuovo-studio-tls","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/leucemia-linfatica-cronica-su-hemasphere-nuovo-studio-tls\/","title":{"rendered":"Leucemia linfatica cronica: su Hemasphere nuovo studio TLS"},"content":{"rendered":"<p>Pubblicato sulla rivista scientifica Hemasphere un nuovo studio dal titolo \u201c<a href=\"https:\/\/doi.org\/10.1002\/hem3.134\">Robust and cost-effective CRISPR\/Cas9 gene editing of primary tumour B cells in E\u00b5-TCL1 model of chronic lymphocytic leukemia<\/a>\u201d a cura della <strong>Tumour Immunology Unit<\/strong> (TUMI) di TLS e dell\u2019Animal Facility di TLS. Il paper descrive l\u2019ottimizzazione di un metodo di modificazione genetica nelle cellule B, notoriamente di difficile manipolazione, tramite la tecnica del CRISPR\/Cas9. I ricercatori coinvolti nello studio sono: Rosita Del Prete, Roberta Drago, Federica Nardi, Gaia Bartolini, Erika Bellini, Antonella De Rosa, Silvia Valensin e Anna Kabanova, coordinatrice scientifica della Tumour Immunology Unit di TLS.<\/p>\n<p>Il paper \u00e8 frutto delle attivit\u00e0 di ricerca sviluppate dalla <strong>Tumour Immunology Unit<\/strong> (TUMI) di TLS che si occupa di studiare uno dei pi\u00f9 frequenti tumori dei linfociti B, la leucemia linfatica cronica (LLC), finora incurabile e soggetta a continue resistenze terapeutiche e ricadute nel 30-40% dei casi. Grazie al supporto iniziale di AIRC e successivamente del consorzio HEAL ITALIA, il progetto di ricerca si pone l\u2019obiettivo di stabilire peculiari vulnerabilit\u00e0 delle cellule LLC che possono essere sfruttate per porre le basi per eventuali nuovi approcci terapeutici. La pubblicazione su Hemasphere \u00e8 frutto della preziosa collaborazione con l\u2019<strong>Animal Facility<\/strong> di TLS, attraverso cui \u00e8 stato possibile perfezionare una strategia che permette di silenziare specifici geni, individuati come potenziali \u201cpromotori\u201d della leucemia o coinvolti nella sua progressione, al fine di comprendere quale sia il loro ruolo <em>in vivo<\/em>, seguendo lo sviluppo della malattia in modelli murini di leucemia linfatica cronica (LLC).<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La pubblicazione \u00e8 frutto della collaborazione tra la TUMI e l\u2019Animal Facility di TLS. <\/p>\n","protected":false},"author":10,"featured_media":22103,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Leucemia linfatica cronica: su Hemasphere nuovo studio TLS - 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