{"id":21692,"date":"2024-06-18T09:28:53","date_gmt":"2024-06-18T07:28:53","guid":{"rendered":"https:\/\/www.toscanalifesciences.org\/?p=21692"},"modified":"2024-06-18T09:30:28","modified_gmt":"2024-06-18T07:30:28","slug":"su-cell-reports-medicine-nuovo-studio-per-il-diabete-mellito-di-tipo-1","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/su-cell-reports-medicine-nuovo-studio-per-il-diabete-mellito-di-tipo-1\/","title":{"rendered":"Su &#8220;Cell Reports Medicine&#8221; nuovo studio per il diabete mellito di tipo 1"},"content":{"rendered":"<p>Pubblicato su \u201c<strong>Cell Reports Medicine<\/strong>\u201d nuovo studio che identifica nuovi biomarcatori per il trattamento personalizzato del diabete mellito di tipo 1. Il paper dal titolo &#8220;<a href=\"https:\/\/www.cell.com\/cell-reports-medicine\/pdf\/S2666-3791(24)00283-0.pdf\"><strong>A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes<\/strong><\/a>&#8221; \u00e8 a cura del team di ricercatori guidato dal professor <strong>Francesco Dotta<\/strong>, ordinario di Endocrinologia all\u2019Ateneo senese e direttore della UOC Diabetologia dell\u2019Azienda ospedaliero-universitaria Senese, che ha il laboratorio di ricerca Fondazione Umberto Di Mario presso la Toscana Life Sciences. I firmatari della pubblicazione sono: Guido Sebastiani, Giuseppina Emanuela Grieco, Marco Bruttini, Stefano Auddino, Alessia Mori, Mattia Toniolli, Daniela Fignani, Giada Licata, Laura Nigi, Caterina Formichi, Alberto Pugliese, Carmella Evans-Molina, Lut Overbergh, Timothy Tree, Mark Peakman, Chantal Mathieu e Francesco Dotta.<\/p>\n<p>Lo studio, finanziato dall\u2019Unione Europea nell\u2019ambito del progetto <strong>INNODIA e dal Ministero dell\u2019Universit\u00e0 e della Ricerca<\/strong> nell\u2019ambito del Centro Nazionale \u201cSviluppo di terapia genica e farmaci con tecnologia a RNA\u201d ha permesso, grazie all&#8217;utilizzo di una tecnologia avanzata di sequenziamento dell\u2019RNA che necessita di pochi microlitri di sangue, di individuare un gruppo di microRNA circolanti che potrebbero diventare preziosi strumenti diagnostici e prognostici per il diabete.<\/p>\n<p>\u201cI microRNA \u2013 ha commentato il professor <strong>Guido Sebastiani<\/strong>, associato di Medicina di Laboratorio all\u2019Universit\u00e0 di Siena e primo autore dello studio &#8211; sono piccole molecole di RNA che regolano molti processi biologici, collegate all&#8217;insorgenza e alla progressione del diabete mellito di tipo 1. In questo lavoro abbiamo analizzato i microRNA presenti nel sangue di un ampio gruppo di persone affette da questa malattia, rivelando un insieme di microRNA derivanti da una specifica regione del cromosoma 14, nota come 14q32, e che \u00e8 anche associata al rischio di sviluppare diabete mellito di tipo 1\u201d.<\/p>\n<p>&#8220;La ricerca &#8211; ha aggiunto il professor <strong>Francesco Dotta<\/strong> &#8211; ha identificato potenziali biomarcatori che potrebbero cambiare il modo in cui comprendiamo e trattiamo il diabete di tipo 1. Questa scoperta, unita all\u2019evidenza che anche il diabete mellito di tipo 1 \u00e8 una malattia eterogenea, offre speranza per terapie pi\u00f9 mirate e personalizzate e quindi per un migliore trattamento della malattia nel prossimo futuro. Sottolineo inoltre che, a oltre un secolo dalla scoperta dell\u2019insulina, a oggi l\u2019unica terapia possibile nei pazienti affetti da diabete mellito di tipo 1, si stanno finalmente sviluppando strategie terapeutiche mirate a proteggere le cellule beta del pancreas, bloccando quelle cellule del sistema immunitario responsabili della comparsa della malattia\u201d.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Il paper \u00e8 a cura del team di ricercatori guidato dal professor Francesco Dotta. <\/p>\n","protected":false},"author":10,"featured_media":21693,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Su &quot;Cell Reports Medicine&quot; nuovo studio per il diabete mellito di tipo 1 - Toscana Life Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/su-cell-reports-medicine-nuovo-studio-per-il-diabete-mellito-di-tipo-1\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Su &quot;Cell Reports Medicine&quot; 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