{"id":15789,"date":"2021-10-12T12:49:48","date_gmt":"2021-10-12T10:49:48","guid":{"rendered":"https:\/\/tls.giangocomunicazione.it\/covid-19-e-diabete-una-ricerca-senese-ne-rivela-il-legame\/"},"modified":"2023-02-04T20:44:56","modified_gmt":"2023-02-04T19:44:56","slug":"covid-19-e-diabete-una-ricerca-senese-ne-rivela-il-legame","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/covid-19-e-diabete-una-ricerca-senese-ne-rivela-il-legame\/","title":{"rendered":"Covid-19 e diabete: una ricerca senese ne rivela il legame"},"content":{"rendered":"<p>Covid e diabete sono legati. Lo dimostra una <strong>ricerca<\/strong> condotta dal <strong>professor Francesco Dotta<\/strong>, direttore del <strong><a href=\"https:\/\/www.unisi.it\/dipartimenti\/dipartimento-scienze-mediche-chirurgiche-e-neuroscienze\">Dipartimento di Scienze Mediche Chirurgiche e Neuroscienze dell\u2019Universit\u00e0 di Siena<\/a><\/strong> e della <a href=\"http:\/\/www.ao-siena.toscana.it\/index.php\/innovazione-sperimentazione-e-ricerca-clinica-e-traslazionale\/diabetologia\"><strong>UOC Diabetologia<\/strong> dell\u2019<strong>Azienda Ospedaliero-Universitaria Senese<\/strong><\/a>, che ha dimostrato come ci sia una diretta connessione tra gli aumenti di casi di diabete, in persone precedentemente sane, dopo aver contratto il SARS-CoV-2.<\/p>\n<p><strong>Lo studio<\/strong>. La ricerca, compiuta in collaborazione con le Universit\u00e0 di <strong><a href=\"https:\/\/www.kuleuven.be\/kuleuven\/\">Leuven<\/a>, <a href=\"https:\/\/www.unipi.it\/\">Pisa <\/a><\/strong>e <strong><a href=\"https:\/\/www.vub.be\/en\/home\">Brussels<\/a><\/strong> e presentata alla comunit\u00e0 scientifica durante il recente <strong>Congresso di Diabetologia<\/strong> ha dimostrato che<strong> il virus SARS-CoV-2 \u00e8 in grado di infettare le cellule beta pancreatiche che producono l\u2019insulina<\/strong>, modificandone cos\u00ec la funzione, legandosi alla proteina ACE2 situata sulla superficie delle cellule che, interagendo con la proteina Spike del SARS-COV2, ne permette l\u2019ingresso nella cellula bersaglio.<\/p>\n<p><a href=\"https:\/\/www.toscanalifesciences.org\/it\/2021\/10\/covid-19-e-diabete-una-ricerca-senese-ne-rivela-il-legame\/dotta_1\/\" rel=\"attachment wp-att-12727\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft  wp-image-12727\" src=\"\/wp-content\/uploads\/2022\/04\/dotta_1.jpg\" alt=\"\" width=\"187\" height=\"281\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Il meccanismo di infezione<\/strong>. \u201c<em>Nel tessuto pancreatico<\/em> \u2013 spiega il professor<strong> Francesco Dotta<\/strong>\u2013<em> la proteina ACE2 \u00e8 aumentata in presenza di processi infiammatori, come durante l\u2019infezione virale. L\u2019effetto antinfiammatorio di farmaci come Nimbus e Baricitinib sui livelli di ACE2 nelle isole pancreatiche hanno dimostrato che queste terapie ne prevengono l&#8217;incremento<\/em>\u201d. \u201c<em>La nostra ricerca<\/em> \u2013 conclude il professor Dotta &#8211; <em>dimostra pertanto non solo il coinvolgimento dell\u2019infezione SARS-CoV-2 nel danneggiare le cellule che producono l\u2019insulina, ma ha anche fornito indicazioni su possibili terapie che contrastano l\u2019infiammazione pancreatica limitando l\u2019insorgenza di iperglicemia e diabete<\/em>\u201d.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Le fasi della ricerca<\/strong>. Numerosi report dimostrano un\u2019ampia diffusione della proteina ACE2 in vari tessuti. Il professor Dotta e il suo gruppo di ricerca hanno studiato il modello di espressione di ACE2 sul tessuto pancreatico di donatori non diabetici, allo scopo di comprendere le connessioni molecolari tra virus e diabete. In particolare, i ricercatori dell\u2019Universit\u00e0 di Siena hanno analizzato i campioni pancreatici nel contesto del consorzio INNODIA, un ampio progetto di ricerca sul diabete (finanziato da<strong> <a href=\"https:\/\/europa.eu\/european-union\/index_it\">Unione europea<\/a><\/strong>, <strong><a href=\"https:\/\/www.jdrf.org\/\">JDRF<\/a><\/strong> e <strong><a href=\"https:\/\/helmsleytrust.org\/\">Helmsely Foundation<\/a><\/strong> nell\u2019ambito dell\u2019iniziativa europea <strong><a href=\"https:\/\/www.imi.europa.eu\/\">Innovative Medicines Initiative, IMI2<\/a><\/strong>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Covid e diabete sono legati. Lo dimostra una ricerca condotta dal professor Francesco Dotta, direttore del Dipartimento di Scienze Mediche&#8230;<\/p>\n","protected":false},"author":1,"featured_media":15791,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Covid-19 e diabete: una ricerca senese ne rivela il legame - Toscana Life Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/covid-19-e-diabete-una-ricerca-senese-ne-rivela-il-legame\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Covid-19 e diabete: una ricerca senese ne rivela il legame - Toscana Life Sciences\" \/>\n<meta property=\"og:description\" content=\"Covid e diabete sono legati. 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