{"id":15741,"date":"2021-08-25T08:47:04","date_gmt":"2021-08-25T06:47:04","guid":{"rendered":"https:\/\/tls.giangocomunicazione.it\/covid-e-trombosi-studio-dell-aou-senese-su-rischio-uomini-over-50\/"},"modified":"2023-02-04T20:44:55","modified_gmt":"2023-02-04T19:44:55","slug":"covid-e-trombosi-studio-dell-aou-senese-su-rischio-uomini-over-50","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/covid-e-trombosi-studio-dell-aou-senese-su-rischio-uomini-over-50\/","title":{"rendered":"Covid e trombosi: studio dell&#8217; AOU Senese su rischio uomini over 50"},"content":{"rendered":"<p>Nuovo studio coordinato dalla Genetica Medica dell\u2019<strong><a href=\"http:\/\/www.ao-siena.toscana.it\/index.php\">Azienda ospedaliero-universitaria Senese,<\/a><\/strong> diretta da <strong>Alessandra Renieri,<\/strong> e pubblicato sul &#8216;<strong>Journal of Hematology and Oncology&#8217;<\/strong> dimostra che il <strong>rischio trombosi<\/strong> \u00e8 pi\u00f9 elevato per gli uomini, positivi al Covid-19, con un\u2019et\u00e0 superiore ai 50 anni o una riduzione del testosterone a causa di un\u2019anomalia genetica.<\/p>\n<p>L\u2019articolo spiega come mai alcuni pazienti che hanno contratto il virus SARS-CoV-2 vanno incontro a maggiori rischi trombotici, specie se si tratta di anziani o soggetti con minor effetto del testosterone (carenza di recettore degli androgeni) e che hanno un difetto in una proteina, gene Selectina P, che innesca il trombo in maniera pi\u00f9 vivace.<\/p>\n<p>\n\u00abIl tromboembolismo \u00e8 una causa frequente di gravit\u00e0 e mortalit\u00e0 nel Covid-19 \u2013 spiega la professoressa <strong>Alessandra Renieri\u00a0<\/strong> &#8211; Tuttavia, l&#8217;eziologia di questo fenomeno non \u00e8 ancora ben compresa. Insieme agli altri centri di ricerca abbiamo selezionato un campione di circa 1200 pazienti, positivi al SARS-CoV-2 ma con diverse gravit\u00e0, e classificati secondo sesso ed et\u00e0. 100 di questi pazienti sono stati reclutati all\u2019ospedale Santa Maria alle Scotte, gli altri provengono da altri 40 centri italiani. Grazie al sequenziamento degli esomi &#8211; prosegue la professoressa Renieri -, \u00e8 stato individuato un gruppo di circa 500 pazienti maschili, di et\u00e0 superiore ai 50 anni, per cui il rischio trombotico era aumentato, per effetto della regolazione del gene SELP dal testosterone. Un\u2019indicazione, questa \u2013 conclude Renieri -, molto importante anche per indicare il percorso terapeutico pi\u00f9 idoneo per ogni soggetto\u00bb.<\/p>\n<p>\nLa ricerca \u00e8 stata realizzata grazie al Consorzio Gen-Covid, grazie ad un finanziamento della <strong>Regione Toscana,<\/strong> e ha visto la partecipazione delle aziende del <strong>Sistema Sanitario Regional<\/strong>e e di altri 40 ospedali in Italia. Fondamentale anche la collaborazione del professor <strong>Andrea Isidori<\/strong>, dell\u2019<strong>Universit\u00e0 La Sapienza di Roma<\/strong>, del dottor <strong>Giuseppe Marotta<\/strong>, direttore Dipartimento Innovazione, Sperimentazione e Ricerca clinica e traslazionale dell\u2019Aou Senese, e del ricercatore <strong>Simone Furini<\/strong> del <strong>Dipartimento Biotecnologie Mediche dell\u2019Universit\u00e0 di Siena.<\/strong><\/p>\n<p>\n\u00abI test sui 1200 pazienti analizzati \u2013 aggiunge <strong>Renieri<\/strong> &#8211; sono stati effettuati con analisi dell\u2019esoma tramite il sequenziatore genomico a disposizione dell&#8217;Aou Senese e acquisito, a dicembre 2019, grazie al sostegno di <strong>Regione Toscana, MIUR, Universit\u00e0 di Siena, Aou Senese, Fondazione Monte dei Paschi di Siena, Toscana Life Sciences, Azienda Usl Toscana sudest.<\/strong> L\u2019apparecchio, unico in Toscana in ambito sanitario e uno dei pochi in Italia del suo genere &#8211; conclude Renieri &#8211; \u00e8 in grado di processare 200 pazienti per notte ed individuare tutti i marcatori utili per la gravit\u00e0 di Covid\u00bb.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nuovo studio coordinato dalla Genetica Medica dell\u2019Azienda ospedaliero-universitaria Senese, diretta da Alessandra Renieri, e pubblicato sul &#8216;Journal of Hematology and&#8230;<\/p>\n","protected":false},"author":1,"featured_media":15742,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Covid e trombosi: studio dell&#039; AOU Senese su rischio uomini over 50 - Toscana Life Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/covid-e-trombosi-studio-dell-aou-senese-su-rischio-uomini-over-50\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Covid e trombosi: studio dell&#039; 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