{"id":15538,"date":"2020-10-15T09:28:36","date_gmt":"2020-10-15T07:28:36","guid":{"rendered":"https:\/\/tls.giangocomunicazione.it\/tls-individua-lanticorpo-monoclonale-piu-potente-contro-il-covid19\/"},"modified":"2020-10-15T09:28:36","modified_gmt":"2020-10-15T07:28:36","slug":"tls-individua-lanticorpo-monoclonale-piu-potente-contro-il-covid19","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/tls-individua-lanticorpo-monoclonale-piu-potente-contro-il-covid19\/","title":{"rendered":"Tls individua l\u2019anticorpo monoclonale pi\u00f9 potente contro il Covid19"},"content":{"rendered":"

Il lavoro del Monoclonal Antibody Discovery (MAD) Lab <\/strong>di Fondazione Toscana Life Sciences<\/strong> prosegue con l’individuazione del MAD0004J08,\u00a0<\/strong>l\u2019anticorpo monoclonale pi\u00f9 potente\u00a0 che\u00a0<\/strong>sar\u00e0 testato nelle prove cliniche previste per fine 2020.<\/p>\n

La selezione \u00e8 caduta su uno dei tre anticorpi migliori, gi\u00e0 individuati a luglio, scelto sia la capacit\u00e0\u00a0 di legare la proteina spike e di inattivare il virus, che per la resa da un punto di vista dello sviluppo e produzione della terapia contro coronavirus SARS-CoV-2 (Progetto MAbCo19).<\/p>\n

Il gruppo di ricerca MAD Lab<\/a><\/strong> di Fondazione Toscana Life Sciences, coordinato dal Dr. <\/strong>Rino Rappuoli<\/a><\/strong>, ha recentemente pubblicato su BioRxiv<\/strong> il lavoro scientifico \u201cExtremely potent human monoclonal antibodies from convalescent Covid-19 patient<\/strong>s\u201d relativo alle evidenze dell\u2019attivit\u00e0 svolta finora. Il preprint, firmato da oltre venti ricercatori<\/strong>, tra i principali a livello nazionale e internazionale delle realt\u00e0 INMI Spallanzani, Toscana Life Sciences, VisMederi, Universit\u00e0 di Siena e Imperial College di Londra, mostra gli avanzamenti dell\u2019attivit\u00e0 di laboratorio che ha selezionato, dal sangue dei pazienti guariti da COVID-19, oltre 4.000 cellule B<\/strong> producendo circa 450 anticorpi<\/strong> da testare, tra i quali lo scorso luglio sono stati individuati i 3 pi\u00f9 promettenti,<\/strong> capaci di neutralizzare due varianti del virus SARS-CoV-2 in vitro con potenza neutralizzante compresa tra 4 e 10 ng\/mL.<\/strong><\/p>\n

I risultati promettenti illustrati nel paper<\/strong> aprono nuove strade sul fronte dell\u2019approccio scientifico, ad esempio l\u2019ipotesi di una combinazione di anticorpi come possibile terapia. Inoltre, risultati preliminari dei test in vivo (sui criceti) mostrano che gli anticorpi monoclonali selezionati agiscono sia come mezzo preventivo che terapeutico<\/strong>. Il gruppo di ricerca di Toscana Life Sciences sta, dunque, lavorando a una pubblicazione per una rivista peer reviewed che raccolga i risultati finora generati incluse le prove in vivo, per le quali i risultati definitivi sono attesi entro la fine di ottobre 2020.<\/p>\n","protected":false},"excerpt":{"rendered":"

Il lavoro del Monoclonal Antibody Discovery (MAD) Lab di Fondazione Toscana Life Sciences prosegue con l’individuazione del MAD0004J08,\u00a0l\u2019anticorpo monoclonale pi\u00f9…<\/p>\n","protected":false},"author":1,"featured_media":15539,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"\nTls individua l\u2019anticorpo monoclonale pi\u00f9 potente contro il Covid19 - Toscana Life Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/tls-individua-lanticorpo-monoclonale-piu-potente-contro-il-covid19\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tls individua l\u2019anticorpo monoclonale pi\u00f9 potente contro il Covid19 - 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