{"id":14912,"date":"2019-01-23T12:03:06","date_gmt":"2019-01-23T11:03:06","guid":{"rendered":"https:\/\/tls.giangocomunicazione.it\/siena-ospita-l-11-international-workshop-on-alkaptonuria-aku-appuntamento-il-30-gennaio\/"},"modified":"2019-01-23T12:03:06","modified_gmt":"2019-01-23T11:03:06","slug":"siena-ospita-l-11-international-workshop-on-alkaptonuria-aku-appuntamento-il-30-gennaio","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/it\/news-e-eventi\/siena-ospita-l-11-international-workshop-on-alkaptonuria-aku-appuntamento-il-30-gennaio\/","title":{"rendered":"Siena ospita l\u2019 11\u00b0 International Workshop on Alkaptonuria (AKU): appuntamento il 30 gennaio"},"content":{"rendered":"<p>Si svolger\u00e0 <strong>mercoledi 30 gennaio<\/strong> <strong>presso il Dipartimento di Biotecnologie, Chimica e Farmacia dell\u2019Universit\u00e0 di Siena<\/strong> l\u2019<em><strong>\u201cInternational Workshop on Alkaptonuria (AKU)\u201d<\/strong><\/em>. Alla sua <strong>undicesima edizione<\/strong>, il workshop propone gli <strong>interventi di esperti di livello nazionale e internazionale<\/strong> sulla patologia, cos\u00ec suddivisi: nelle sessioni mattutine gli aspetti medici del contesto Italiano (Chair: Prof. Frediani) e del contesto internazionale (Chair: Prof. Ranganath); nelle sessioni pomeridiane la diagnostica per immagini (Chair: Prof. Gallagher), Nuovi insight sui meccanismi molecolari e sulle prospettive terapeutiche (Chair: Prof. Santucci) .<br \/>La partecipazione \u00e8 gratuita, previa registrazione al link: <a href=\"https:\/\/goo.gl\/forms\/M6EJSjYnOzEEnqch2\" target=\"_blank\" rel=\"noopener\">https:\/\/goo.gl\/forms\/M6EJSjYnOzEEnqch2<\/a><\/p>\n<p>L\u2019<strong>Alcaptonuria<\/strong>\u00a0(AKU) \u00e8 una <strong>malattia genetica rara<\/strong>, ereditaria, che ha effetti sul catabolismo degli amminoacidi aromatici fenilalanina e tirosina. La malattia \u00e8 <strong>caratterizzata da un difetto nella funzione dell&#8217;enzima omogentisato 1,2-diossigenasi<\/strong>, cui consegue l&#8217;accumulo nel sangue e nelle urine dell&#8217;ossido dell&#8217;acido omogentisico, detto alcaptone. Questo metabolita della tirosina <strong>pu\u00f2 causare un danno articolare<\/strong> (che pu\u00f2 condurre all&#8217;osteoartrosi),<strong> cardiaco<\/strong> (specialmente di tipo valvolare) <strong>e renale<\/strong> (formazione di calcoli).\u00a0<br \/>I danni alla cartilagine e alla pelle sono causati da un pigmento nero chiamato ocronosi, che causa l\u2019erosione della cartilagine e l&#8217;insorgenza di osteoartrite.<br \/>Si tratta di una <strong>patologia degenerativa e invalidante nonch\u00e9 \u201corfana\u201d<\/strong> (che ancora non beneficia di una terapia).<\/p>\n<p>Per informazioni sul Workshop: Scarica <a href=\"http:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2019\/01\/flyer-11th-AKU-workshop_Programma.pdf\" target=\"_blank\" rel=\"noopener\">Programma<\/a> &#8211; Scarica <a href=\"http:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2019\/01\/locandina-A4-11th-AKU-workshop.pdf\" target=\"_blank\" rel=\"noopener\">Locandina<\/a><br \/>Per maggiori informazioni su TLS e alcaptonuria: <a href=\"https:\/\/canale3.tv\/alcaptonuria-studenti-lo-scoprono-a-tls\/\" target=\"_blank\" rel=\"noopener\">\u201cScienziati per un Giorno\u201d \u2013 edizione febbraio 2018<\/a>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Si svolger\u00e0 mercoledi 30 gennaio presso il Dipartimento di Biotecnologie, Chimica e Farmacia dell\u2019Universit\u00e0 di Siena l\u2019\u201cInternational Workshop on Alkaptonuria&#8230;<\/p>\n","protected":false},"author":1,"featured_media":14913,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - 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