{"id":22944,"date":"2025-04-03T13:44:33","date_gmt":"2025-04-03T11:44:33","guid":{"rendered":"https:\/\/www.toscanalifesciences.org\/?p=22944"},"modified":"2025-04-03T13:44:33","modified_gmt":"2025-04-03T11:44:33","slug":"a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d","status":"publish","type":"post","link":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/","title":{"rendered":"A Guido Sebastiani il Career Development Award da Breakthrough T1D"},"content":{"rendered":"<p><strong>Guido Sebastiani<\/strong>, ricercatore nel campo della biologia molecolare e del diabete dell\u2019<strong>Universit\u00e0 di Siena<\/strong>, ha ricevuto il <strong>Career Development Award da Breakthrough T1D,<\/strong> principale organizzazione no profit statunitense dedicata al supporto della ricerca internazionale sul diabete di tipo 1, per l\u2019innovativo progetto di ricerca intitolato &#8220;DISentangling circulating non-coding RNAs Complexity by tracking their expression and Origin in Type 1 Diabetes (DISCO-T1D)\u201d, condotto dal team di ricerca che lavora presso la <strong>Fondazione Toscana Life Sciences<\/strong> sotto il coordinamento del professor<strong> Francesco Dotta<\/strong>.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-22947\" src=\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Guido-Sebastiani.jpg\" alt=\"\" width=\"297\" height=\"290\" \/>Il <strong>Career Development Award di Breakthrough T1D<\/strong> \u00e8 progettato per offrire a scienziati qualificati e promettenti, nelle prime fasi della loro carriera, l&#8217;opportunit\u00e0 di affermarsi in ambiti in linea con le strategie di ricerca di Breakthrough T1D. Promuovendo collaborazioni interdisciplinari e sostenendo sia la ricerca di base che quella clinica, Breakthrough T1D mira ad accelerare la ricerca innovativa e le scoperte scientifiche per curare, trattare e prevenire il diabete di tipo 1 (T1D) e le sue complicanze.<\/p>\n<p>Il <strong>progetto<\/strong> mira a colmare una lacuna critica nella comprensione della patogenesi del T1D, identificando<strong> nuovi biomarcatori di RNA<\/strong> non codificante circolanti nel sangue. Questi biomarcatori hanno il potenziale di rivoluzionare il modo in cui il diabete di tipo 1 viene diagnosticato e trattato, offrendo un approccio di &#8220;biopsia liquida&#8221; in grado di rilevare la malattia in modo precoce e guidare interventi terapeutici pi\u00f9 personalizzati. Il progetto DISCO-T1D adotta un approccio multidisciplinare, combinando tecniche avanzate di biologia molecolare, bioinformatica e ricerca clinica. Utilizzer\u00e0 il sequenziamento di RNA e analisi avanzate dei dati per costruire il database pi\u00f9 completo di RNA non codificanti circolanti associati al T1D. Il progetto esplorer\u00e0 anche le origini cellulari di questi RNA per comprendere meglio il loro ruolo nella progressione della malattia e nella risposta alle immunoterapie. La ricerca contribuir\u00e0 in modo significativo agli sforzi in corso per stratificare i pazienti con T1D in base ai loro profili biomolecolari unici, aprendo la strada a trattamenti pi\u00f9 efficaci e personalizzati. Si prevede che avr\u00e0 un impatto significativo nello sviluppo di terapie innovative e nella gestione complessiva del diabete di tipo 1.<\/p>\n<p>Clicca <strong><a href=\"https:\/\/www.unisi.it\/unisilife\/notizie\/al-prof-sebastiani-il-career-development-award-da-breakthrough-t1d\">qui<\/a><\/strong> per leggere il comunicato stampa.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Riconoscimento per gli studi sui biomarcatori per la diagnosi precoce del diabete. <\/p>\n","protected":false},"author":10,"featured_media":22945,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Guido Sebastiani il Career Development Award da Breakthrough T1D - Toscana Life Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Guido Sebastiani il Career Development Award da Breakthrough T1D - Toscana Life Sciences\" \/>\n<meta property=\"og:description\" content=\"Riconoscimento per gli studi sui biomarcatori per la diagnosi precoce del diabete.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/\" \/>\n<meta property=\"og:site_name\" content=\"Toscana Life Sciences\" \/>\n<meta property=\"article:published_time\" content=\"2025-04-03T11:44:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"393\" \/>\n\t<meta property=\"og:image:height\" content=\"295\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"marilena82\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"marilena82\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/\"},\"author\":{\"name\":\"marilena82\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/person\/6b9c5bc01fe1785014cd56ee8c496af6\"},\"headline\":\"A Guido Sebastiani il Career Development Award da Breakthrough T1D\",\"datePublished\":\"2025-04-03T11:44:33+00:00\",\"dateModified\":\"2025-04-03T11:44:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/\"},\"wordCount\":366,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/\",\"url\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/\",\"name\":\"A Guido Sebastiani il Career Development Award da Breakthrough T1D - Toscana Life Sciences\",\"isPartOf\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg\",\"datePublished\":\"2025-04-03T11:44:33+00:00\",\"dateModified\":\"2025-04-03T11:44:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage\",\"url\":\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg\",\"contentUrl\":\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg\",\"width\":393,\"height\":295},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.toscanalifesciences.org\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A Guido Sebastiani il Career Development Award da Breakthrough T1D\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#website\",\"url\":\"https:\/\/www.toscanalifesciences.org\/en\/\",\"name\":\"Toscana Life Sciences\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.toscanalifesciences.org\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#organization\",\"name\":\"Toscana Life Sciences\",\"url\":\"https:\/\/www.toscanalifesciences.org\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2022\/08\/index.png\",\"contentUrl\":\"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2022\/08\/index.png\",\"width\":191,\"height\":66,\"caption\":\"Toscana Life Sciences\"},\"image\":{\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/person\/6b9c5bc01fe1785014cd56ee8c496af6\",\"name\":\"marilena82\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/90da85e7baa9a1ffaa3e9eec5271dd0f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/90da85e7baa9a1ffaa3e9eec5271dd0f?s=96&d=mm&r=g\",\"caption\":\"marilena82\"},\"url\":\"https:\/\/www.toscanalifesciences.org\/en\/author\/marilena82\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A Guido Sebastiani il Career Development Award da Breakthrough T1D - Toscana Life Sciences","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/","og_locale":"en_US","og_type":"article","og_title":"A Guido Sebastiani il Career Development Award da Breakthrough T1D - Toscana Life Sciences","og_description":"Riconoscimento per gli studi sui biomarcatori per la diagnosi precoce del diabete.","og_url":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/","og_site_name":"Toscana Life Sciences","article_published_time":"2025-04-03T11:44:33+00:00","og_image":[{"width":393,"height":295,"url":"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg","type":"image\/jpeg"}],"author":"marilena82","twitter_card":"summary_large_image","twitter_misc":{"Written by":"marilena82","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#article","isPartOf":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/"},"author":{"name":"marilena82","@id":"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/person\/6b9c5bc01fe1785014cd56ee8c496af6"},"headline":"A Guido Sebastiani il Career Development Award da Breakthrough T1D","datePublished":"2025-04-03T11:44:33+00:00","dateModified":"2025-04-03T11:44:33+00:00","mainEntityOfPage":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/"},"wordCount":366,"commentCount":0,"publisher":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/#organization"},"image":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage"},"thumbnailUrl":"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/","url":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/","name":"A Guido Sebastiani il Career Development Award da Breakthrough T1D - Toscana Life Sciences","isPartOf":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage"},"image":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage"},"thumbnailUrl":"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg","datePublished":"2025-04-03T11:44:33+00:00","dateModified":"2025-04-03T11:44:33+00:00","breadcrumb":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#primaryimage","url":"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg","contentUrl":"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2025\/04\/Team2.jpg","width":393,"height":295},{"@type":"BreadcrumbList","@id":"https:\/\/www.toscanalifesciences.org\/en\/uncategorized\/a-guido-sebastiani-il-career-development-award-da-breakthrough-t1d\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.toscanalifesciences.org\/en\/"},{"@type":"ListItem","position":2,"name":"A Guido Sebastiani il Career Development Award da Breakthrough T1D"}]},{"@type":"WebSite","@id":"https:\/\/www.toscanalifesciences.org\/en\/#website","url":"https:\/\/www.toscanalifesciences.org\/en\/","name":"Toscana Life Sciences","description":"","publisher":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.toscanalifesciences.org\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.toscanalifesciences.org\/en\/#organization","name":"Toscana Life Sciences","url":"https:\/\/www.toscanalifesciences.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2022\/08\/index.png","contentUrl":"https:\/\/www.toscanalifesciences.org\/wp-content\/uploads\/2022\/08\/index.png","width":191,"height":66,"caption":"Toscana Life Sciences"},"image":{"@id":"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/person\/6b9c5bc01fe1785014cd56ee8c496af6","name":"marilena82","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.toscanalifesciences.org\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/90da85e7baa9a1ffaa3e9eec5271dd0f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/90da85e7baa9a1ffaa3e9eec5271dd0f?s=96&d=mm&r=g","caption":"marilena82"},"url":"https:\/\/www.toscanalifesciences.org\/en\/author\/marilena82\/"}]}},"_links":{"self":[{"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/posts\/22944"}],"collection":[{"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/comments?post=22944"}],"version-history":[{"count":1,"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/posts\/22944\/revisions"}],"predecessor-version":[{"id":22949,"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/posts\/22944\/revisions\/22949"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/media\/22945"}],"wp:attachment":[{"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/media?parent=22944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/categories?post=22944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.toscanalifesciences.org\/en\/wp-json\/wp\/v2\/tags?post=22944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}