{"id":16643,"date":"2022-01-30T09:59:57","date_gmt":"2022-01-30T08:59:57","guid":{"rendered":"https:\/\/tls.giangocomunicazione.it\/servizi-di-ricerca-conto-terzi\/"},"modified":"2026-10-15T11:28:47","modified_gmt":"2026-10-15T09:28:47","slug":"research-services-for-third","status":"publish","type":"page","link":"https:\/\/www.toscanalifesciences.org\/en\/research-services-for-third\/","title":{"rendered":"Research Services for Third Parties"},"content":{"rendered":"
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[vc_custom_heading text=”RESEARCH SERVICES FOR THIRD PARTIES” font_container=”tag:h2|text_align:center” use_theme_fonts=”yes” css=”%7B%22default%22%3A%7B%22color%22%3A%22%23015294%22%2C%22font-weight%22%3A%22400%22%2C%22text-transform%22%3A%22uppercase%22%7D%7D”]

Thanks to the expertise and experience of its scientific and technical staff,\u00a0 TLS\u00a0 supports researchers and companies in carrying out a wide range of experimental activities.<\/strong> To this end, TLS provides know-how, technological platforms, and analytical instrumentation for research activities in the biological and molecular fields<\/strong>, continuously expanding and strengthening its research service offering through the implementation of new platforms.<\/p>\n

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The main services and technological platforms include:<\/p>\n

\u2022 PROTEOMICS, METABOLOMICS AND MOLECULAR PROFILING<\/strong> (Q-Exactive HF-X high-resolution mass spectrometer coupled with nano-flow UPLC): development of customized protocols for matrices of various origins;<\/p>\n

\u2022 ANALYSIS OF BOTANICAL AND\/OR NUTRACEUTICAL SAMPLES<\/strong> (Q-Exactive Plus mass spectrometer coupled with UPLC equipped with a DAD detector);<\/p>\n

\u2022 Development of custom in vitro cellular models<\/strong> for toxicity, efficacy, and absorption testing of botanical and\/or nutraceutical products;<\/p>\n

\u2022 Opera Phenix HIGH CONTENT SCREENING<\/strong> System, a state-of-the-art instrument for high-throughput analysis, phenotype screening, and investigations on complex disease models, including live-cell experiments, primary cultures, 3D cell cultures, and microtissues;<\/p>\n

\u2022 BSL-3 PATHOGEN CONTAINMENT LABORATORY;<\/strong><\/p>\n

\u2022 BIOINFORMATICS<\/strong>, providing established bioinformatics analysis approaches, recently enhanced with neural network- and AI-based data mining methods, for the development of customized pipelines for processing proteomic and metabolomic data generated through mass spectrometry;<\/p>\n

\u2022 ANTIBODY GENERATION AND PRODUCTION<\/strong>
\n\u2013 Production and purification of recombinant proteins in mammalian cells.
\n\u2013 Immunogenicity studies and production of polyclonal antibodies in mice and rabbits.
\n\u2013 Identification and cloning of monoclonal antibodies from human, mouse, and rabbit sources using single-cell technology.
\n\u2013 Expression and purification of recombinant monoclonal antibodies.
\n\u2013 Next-generation antibody engineering (including bispecific antibodies).
\n\u2013 Binding assays.
\n\u2013 Real-time protein-protein\/protein-small molecule kinetics (ka, kd, KD), concentration\/titer assays (IgG), and epitope mapping.
\n\u2013 Developability assessment (thermal stability, colloidal stability, and application of molecular dynamics and deep learning technologies to improve binding, stability, and expression).
\n\u2013 In vitro functional characterization of monoclonal antibodies in BSL-2 and BSL-3 environments.<\/p>\n

\u2022 GENE EDITING<\/strong> using CRISPR\/Cas9 technology in cell lines and primary cells that are difficult to manipulate.<\/p>\n

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Contact us<\/a><\/p>\n<\/div><\/div>[vc_custom_heading text=”QUALITY POLICY: ISO 9001:2015 Certification for the TLS Mass Spectrometry Unit” font_container=”tag:h2|text_align:center” use_theme_fonts=”yes” css=”%7B%22default%22%3A%7B%22color%22%3A%22%23015294%22%2C%22font-weight%22%3A%22400%22%2C%22text-transform%22%3A%22uppercase%22%7D%7D”]

TLS is ISO 9001:2015 certified for \u201cResearch, development, design and delivery of services (analytical testing) based on mass spectrometry and in vitro assays, including related bioinformatic data processing\u201d (No. Q\/1765\/24) for its Mass Spectrometry Unit (MSU), a certification obtained on 7 March 2024.<\/strong> This achievement is the result of the active involvement of TLS staff and promotes and strengthens a culture of quality throughout TLS, through continuous investment in training and the development of rigorous protocols and tools to ensure greater quality, reliability, traceability, confidentiality, and integrity of the methods and data generated through scientific research activities.<\/p>\n

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This process led to the establishment of a team of auditors<\/strong> responsible for monitoring the ISO system and quality management, trained according to the UNI EN ISO 19011:2018 standard.<\/strong> A key element of the ISO framework is the collaboration with the Privacy Team<\/strong>, which supports the implementation of appropriate security measures to protect sensitive information, ensure privacy and corporate confidentiality, manage risks, and promote good documentation practices through validation activities and internal audits.<\/p>\n

In particular, the services provided by the MSU in compliance with ISO 9001:2015 include the research, development, design, and delivery of analytical services based on mass spectrometry, bioinformatic data processing, and in vitro testing.<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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[vc_custom_heading text=”TLS Services” font_container=”tag:h2|text_align:center” use_theme_fonts=”yes” css=”%7B%22default%22%3A%7B%22color%22%3A%22_content_primary%22%2C%22font-weight%22%3A%22400%22%2C%22text-transform%22%3A%22uppercase%22%7D%7D”]<\/div><\/div><\/div><\/div><\/div><\/section>
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TLS\u00a0 supports researchers and companies in carrying out a wide range of experimental activities.<\/strong> To this end, TLS provides know-how, technological platforms, and analytical instrumentation for research activities in the biological and molecular fields<\/strong>, continuously expanding and strengthening its research service offering through the implementation of new platforms.<\/p>\n

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The Fondazione TLS provides the workspace, technological facilities and services required to set up a company operating in the life sciences sector.<\/p>\n<\/div><\/div>[vc_raw_html el_class=”btn_center_scarica”]JTNDYSUyMGhyZWYlM0QlMjIlMkZlbiUyRmluY3ViYXRvci1zZXJ2aWNlcyUyRiUyMiUyMGNsYXNzJTNEJTIyc2NhcmljYV9idG4lMjIlM0VSZWFkJTIwTW9yZSUyMCUzQ2klMjBjbGFzcyUzRCUyMmZhcyUyMGZhLWFuZ2xlLXJpZ2h0JTIyJTNFJTNDJTJGaSUzRSUzQyUyRmElM0U=[\/vc_raw_html]<\/div><\/div><\/div><\/div><\/div><\/section>\n","protected":false},"excerpt":{"rendered":"[vc_custom_heading text=\"RESEARCH SERVICES FOR THIRD PARTIES\" font_container=\"tag:h2|text_align:center\" use_theme_fonts=\"yes\" css=\"%7B%22default%22%3A%7B%22color%22%3A%22%23015294%22%2C%22font-weight%22%3A%22400%22%2C%22text-transform%22%3A%22uppercase%22%7D%7D\"]Thanks to the expertise and experience of its scientific and technical staff,\u00a0...","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"yoast_head":"\nResearch Services for Third Parties - 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