Department of Medical Sciences, Surgical and Neurosciences (DSMNC)
The Department of Medical Sciences, Surgical and Neurosciences (DSMNC) was born from the desire to aggregate the initial proposal of three Departments of the University of Siena thus favouring a broad aggregation in a context of organic continuity among the Scientific-Disciplinary Sectors. DSMNC promotes teaching and research activities in the Area of Biomedical and Medical Sciences and is an active part of the Tuscany Regional Centre for Precision Medicine (CReMeP).
Research activities cross multiple contexts and are aimed at the identification of novel molecular mechanisms of various diseases, including metabolic disorders, endocrine, neurodegenerative, cancer and immune-mediated diseases, as well as at the identification of innovative biomarkers in order to foster a broad development of precision and personalized medicine. The development and implementation of high-throughput platforms for nucleic acid sequencing and analysis and the existence of an advanced high-resolution microscopy image analysis platforms and expertise represent two of the multiple strengths upon which the translational research activities of the DSMCN are based.
DSMNC research lab has a strong know-how on the analysis of multiples biomarkers molecules (e.g. small RNAs) from biological fluids in several metabolic/endocrine and immune-related disease contexts. Researchers of DSMNC have recently developed a standardized platform for sequencing analysis of small RNAs from biological fluids. Moreover, high-throughput molecular solutions (exome, whole genome, microbiome sequencing) have been well established, alongside with a solid expertise in confocal microscopy, whole slide fluorescence microscopy and laser capture microdissection analysis.