Bioinformatics Laboratory, Institute of Informatics and Telematics of the National Research Council (IIT-CNR)
The Bioinformatics Laboratory's research focuses on the development of computational and analytical methods to transform experimental molecular and clinical data into relevant information to improve clinical decision-making in the field of Precision Medicine. The approach is multidisciplinary combining mathematics, statistics and computer science.
Researchers have a wide expertise in analyzing high-throughput data (whole and exome seq, RNAseq, small RNAseq), and in developing novel computational methods for copy number variation (CNV) identification from HTS data and their characterization. Further research interests include the study of patient specific tumor heterogeneity; the characterization of the functional role of microRNAs and their regulatory networks in tumor drug resistance mechanisms and in cardiac pathogenesis; the identification of non-invasive biomarkers for therapeutic oncological monitoring and drug resistance.